Background: Hyperthyroidism remains as one of the endocrinology disorders that have broad effect through the patient’s body system. Recent evidence shows that hyperthyroidism could lead to impairment of insulin activity.
Objective: This mini systematic review addresses the correlation between overt hyperthyroidism that could lead into insulin resistance state.
Methods: Literature searching through four databases, which are PubMed®, Cochrane Library®, PROQUEST®, and SCOPUS® was performed. Articles were appraised for validity, importance, and applicability.
Results: There were six studies met the criteria before critical appraisal is conducted. Five of six studies showed significant linear correlation between overt hyperthyroidism and insulin resistance. Two studies also showed that overt hyperthyroidism altered insulin sensitivity in post-prandial state. Each of studies also studied any components which suggestively contributed to insulin resistance developing, i.e. glucagon and ghrelin hormone, glucose intolerance (as performed by OGTT)
Conclusion: Insulin resistance is commonly developed in patients with overt hyperthyroidism, either in fasting or postprandial state. Pathogenesis-related to development of insulin resistance as a consequence of overt hyperthyroidism should be determined briefly as there are many pathways have their role contributed to this condition.