The aim is to explore the relationship between hyperthyroidism, iodine, anti-thyroid drugs (propylthiouracil) and vascular endothelial injury.
1.Totally, 136 SD rats were randomly allocated into control,the hyperthyroidism, the hyperthyroidism propylthiouracil, the hyperthyroidism low iodine, the high iodine, and the endothelial injury group. Rats were raised for 60 days and determined the von Willebrand Factor, Thrombomodulin, nitric oxide, endothelin 1, and Pselectin. Additional indicators included the plant haemagglutinin sample type oxidized low density lipoprotein receptor 1(LOX1) from the aorta, and the number of endothelial progenitor cells (EPCs) in whole blood. The hyperthyroidism group had significantly higher serum values for vWF, TM, NO, ET1, and Pselectin and a higher number of EPCs in whole blood compared with the control group; the abdominal aorta LOX1 expression was also significantly higher in the hyperthyroidism group. The electron microscope showed that hyperthyroidism does cause a certain degree of endothelial injury to the abdominal aorta in rats. Hyperthyroidism can damage the vascular endothelium and is a high risk factor for cardiocerebrovascular disease. Propylthiouracil could be used in the treatment of hyperthyroidism, thus protecting endothelial cells from damage.
2.Through the population experiments, to find the relationship between cardiocerebrovascular disease and hyperthyroidism and autoimmune diseases. Blood samples were collected from clinical diagnosed hyperthyroidism patients, patients with autoimmune thyroid disease, patients with cardiocerebrovascular disease and healthy and authyroid people through physical examination in hospital, sixty cases in each group, and were tested vascular endothelium injury index (VWF, TM, ET1, Pselectin). Patients with simple hyperthyroidism and with autoimmune thyroid diseases have higher endothelial injury levels in whole blood than control group; abnormal thyroid function exists in patients with cardiocerebrovascular diseases and is higher than normal group. Hyperthyroidism can cause vascular endothelium injury, simple hyperthyroidism and autoimmune thyroid diseases are high risk factors of the cardiocerebrovascular disease.