Noriyuki Koibuchi
Noriyuki Koibuchi, M.D., Ph.D.
Professor and Director, Department of Integrative Physiology
Gunma University Graduate School of Medicine
3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan
Tel: +81-27-220-7923, Fax: +81-27-220-7926
Email: nkoibuch@gunma-u.ac.jp
1985 M.D. Gunma University School of Medicine, Maebashi, Gunma, Japan
1989 Ph.D. Institute of Endocrinology, Gunma University, Maebashi, Gunma, Japan.
1989 Postdoctoral Fellow, The Rockefeller University, New York
1991 Assistant Professor of Physiology, Dokkyo University School of Medicine, Tochigi, Japan
1996 Visiting Assistant Professor of Medicine, Harvard Medical School, and Research Associate of Medicine, Brigham and Women's Hospital, Boston
2001- Professor of Integrative Physiology, Gunma University Graduate School of Medicine, Japan
2012- Vice President, Physiological Society of Japan
2016- Vice President, Japan Society of Endocrine Disrupters Research
Award and Honors
1997 American Thyroid Association Research Grand Award
1997 William Randolph Hearst Fund, Harvard Medical School
2000 Quest Diagnostics Young Investigators Award, Endocrine Society
2005 Investigator’s Award, Japan Endocrine Society
2006 Basic Researcher’ Award, Japan Thyroid Association
Major Clincial/Research Field:
Endocrinology (Thyroidology), Environmental Physiology, Neurotoxicology
Selected 10 publications for recent 3 years
1. Amano I, Takatsuru Y, Aghnia Khairinisa M, Kokubo M, Haijima A, Koibuchi N. Effects of perinatal mild hypothyroidism on learning and memory function of adult male offspring. Endocrinology 159: 1910-1921, 2018.
2. Ariyani W, Iwasaki T, Miyazaki W, Yu L, Takeda S, Koibuchi N. Genistein and daidzein affect the thyroid hormone receptor (TR)-mediated transcription through direct binding to TR in vitro. Toxicol Sci 164:417-427, 2018.
3. Khairinisa MA, Takatsuru Y, Amano I, Kokubo M, Haijima A, Miyazaki W, Koibuchi N. In utero and postnatal propylthiouracil-Induced mild hypothyroidism impairs maternal behavior in mice. Front Endocrinol 9:228 (eCollection), 2018.
4. Khairinisa MA, Takatsuru Y, Amano I, Khongorzul E, Nakajima T, Kameo S, Koyama H, Tsushima Y, Koibuchi N. The effect of perinatal gadolinium-based contrast agents on adult mice behavior. Invest Radiol 53: 110-118, 2018.
5. Ariyani W, Khairinisa MA, Perrotta G, Manto M, Koibuchi N. The effects of gadolinium-based contrast agents on cerebellum: From basic research to neurological practice and from pregnancy to adulthood Cerebellum. Cerebellum 17: 247-251, 2018.
6. Sairenji TJ, Ikezawa J, Kaneko R, Masuda S, Uchida K, Takanashi Y, Masuda H, Sairenji T, Amano I, Takatsuru Y, Sayama K, Haglund K, Dikic I, Koibuchi N, Shimokawa N. Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring Proc Natl Acad Sci USA 114: 13042-47, 2017.
7 Haijima A, Lesmana R, Shimokawa N, Amano I, Takatsuru Y, Koibuchi N. Differential neurotoxic effects of in utero and lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) on spontaneous locomotor activity and motor coordination in young adult male mouse. J Toxicol Sci 42: 407-416, 2017.
8. Ariyani W, Iwasaki T, Miyazaki W, Khongorzul E, Nakajima T, Kameo S, Koyama H, Tsushima Y, Koibuchi N. Effects of gadolinium-based contrast agents on thyroid hormone receptor action and thyroid hormone-induced cerebellar Purkinje cell morphogenesis. Front Endocrinol 7: 115 (eCollection), 2016.
9. Koibuchi N. Differential hepatic gene expression profile and histone modification after acute or chronic hyperthyroidism, or during remission. Endocrinology 157: 1326-1327, 2016.
10. Amano I, Takatsuru Y, Toya S, Haijima A, Iwasaki T, Grasberger H, Refetoff S, Koibuchi N. Aberrant cerebellar development in mice lacking dual oxidase maturation factors. Thyroid 26: 741-752, 2016.